Command-Shift S = 'Save As…' in BBEdit 6.1
I just noticed that BBEdit 6.1 has a nifty little ‘Set Menu Keys…’ item in the ‘Edit’ menu. This allows you (among other things) to set ‘Command-Shift-S’ to the more oft-seen ‘Save as’ instead of ‘Save to FTP’ as is the application’s default for the key-command. I’m not sure if 6 or 5 has this option, I just noticed it with 6.1